ea0070yi2 | Young Investigators | ECE2020
Chartoumpekis Dionysios
, Ziros Panos
, Habeos Ioannis
, Kyriazopoulou Venetsana
, Smith Adam
, Marques Ana Claudia
, Sykiotis Gerasimos
Introduction: Nrf2 (Nfe2l2) is a transcription factor that regulates a series of cytoprotective and antioxidant enzymes. Upon exposure to oxidative or electrophilic stress, Nrf2 enters the nucleus and induces its target genes expression. Follicular thyroid cells have physiologically high levels of reactive oxygen species as oxidation of iodine is essential for iodination of thyroglobulin and thyroid hormones synthesis. We have shown previously that Nrf2 pathway is active in th...